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Sci Rep, 2026

2021;100: e26893

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doi: 10.1016/j.freeradbiomed.2008.05.014

*Correspondence: Tongwen Sun, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

3 Alterations in Inflammatory profile during obesity and diabetes type 2 The inflammatory state originates largely from dysfunctional adipose tissue and altered immune cell activity, leading to the release of numerous cytokines that modulate insulin signaling and metabolic homeostasis